In this course you’ll learn various statistics topics including multiple testing problem, error rates, error rate controlling procedures, false discovery rates, q-values and exploratory data analysis. We then introduce statistical modeling and how it is applied to high-throughput data. In particular, we will discuss parametric distributions, including binomial, exponential, and gamma, and describe maximum likelihood estimation. We provide several examples of how these concepts are applied in next generation sequencing and microarray data. Finally, we will discuss hierarchical models and empirical bayes along with some examples of how these are used in practice. We provide R programming examples in a way that will help make the connection between concepts and implementation. Given the diversity in educational background of our students we have divided the series into seven parts. You can take the entire series or individual courses that interest you. If you are a statistician you should consider skipping the first two or three courses, similarly, if you are biologists you should consider skipping some of the introductory biology lectures. Note that the statistics and programming aspects of the class ramp up in difficulty relatively quickly across the first three courses. By the third course will be teaching advanced statistical concepts such as hierarchical models and by the fourth advanced software engineering skills, such as parallel computing and reproducible research concepts. These courses make up two Professional Certificates and are self-paced: Data Analysis for Life Sciences: PH525.1x: Statistics and R for the Life Sciences PH525.2x: Introduction to Linear Models and Matrix Algebra PH525.3x: Statistical Inference and Modeling for High-throughput Experiments PH525.4x: High-Dimensional Data Analysis Genomics Data Analysis: PH525.5x: Introduction to Bioconductor PH525.6x: Case Studies in Functional Genomics PH525.7x: Advanced Bioconductor This class was supported in part by NIH grant R25GM114818.
An excellent online course offered by edX: how it works
edX courses consist of weekly learning sequences. Each learning sequence is composed of short videos interspersed with interactive learning exercises, where students can immediately practise the concepts from the videos. The courses often include tutorial videos that are similar to small on-campus discussion groups, an online textbook, and an online discussion forum where students can post and review questions and comments to each other and teaching assistants. Where applicable, online laboratories are incorporated into the course.
edX offers certificates of successful completion and some courses are credit-eligible. Whether or not a college or university offers credit for an online course is within the sole discretion of the school. edX offers a variety of ways to take courses, including verified courses where students have the option to audit the course (no cost) or to work toward an edX Verified Certificate (fees vary by course). edX also offers XSeries Certificates for completion of a bundled set of two to seven verified courses in a single subject (cost varies depending on the courses).
An edX learning programme under Other Experiences
